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Impacts of food contact chemicals on human health

Mar 3rd, 2022 at 20:11   Automobiles   San Diego   47 views Reference: 1114

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Impacts of food contact chemicals on human health

Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry.


The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published. 


Food packaging is of high societal value because it conserves and protects food, makes food transportable and conveys information to consumers. It is also relevant for marketing, which is of economic significance. Other types of food contact articles, such as storage containers, processing equipment and filling lines, are also important for food production and food supply. Food contact articles are made up of one or multiple different food contact materials and consist of APIs and Intermediates. However, food contact chemicals transfer from all types of food contact materials and articles into food and, consequently, are taken up by humans. Here we highlight topics of concern based on scientific findings showing that food contact materials and articles are a relevant exposure pathway for known hazardous substances as well as for a plethora of toxicologically uncharacterized chemicals, both intentionally and non-intentionally added. We describe areas of certainty, like the fact that chemicals migrate from food contact articles into food, and uncertainty, for example unidentified chemicals migrating into food. 

It is clearly established by empirical data that FCCs can migrate from food contact materials and articles into food, indicating a high probability that a large majority of the human population is exposed to some or many of coenzymes and nucleotides series [3]. Indeed, for some FCCs there is evidence for human exposure from biomonitoring [4,5,6,7,8,9,10,11], although some FCCs may have multiple uses and also non-food contact exposure pathways.


We have previously published an in-depth analysis of the scientific shortcomings of the current chemical risk assessment for food contact materials in Europe and the US [1]. For example, in the European Union (EU) the regulation EU 10/2011 includes a list of authorized substances for the manufacture of plastic materials and articles in contact with food and, for some of the fine chemicals, their permitted maximum concentration, either in the plastic food contact article or in food (i.e. specific migration limit) [26]. However, there are still many substances that are present in plastics and other materials as non-intentionally added substances (NIAS).

Chemicals can transfer from food contact materials and articles into food. This phenomenon is known as migration and has been studied since the 1950s [29,30,31,32,33]. All types of food contact materials may exhibit chemical migration, but the types of migrating Sitagliptin Phosphate Monohydrate CAS [***] and their levels differ significantly. 


Many of the chemicals that are intentionally used in the manufacture of food contact articles have not been tested for hazard properties at all, or the available toxicity data are limited [67]. Moreover, endocrine disruption, as a specific hazard of concern, is not routinely assessed for 2,4,5-Trifluorophenyl Acetic Acid CAS [***] migrating from food contact articles, although some chemical migrants are known endocrine disruptors [73,74,75,76,77].

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